1,4-disubstituted piperazines

Details 1,4-disubstituted piperazines 1,4-disubstituted piperazines

1991-07-11

1993-01-05

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544379, A61K 31495, C07D40914, C07D40912

Patent

active

051770776

ABSTRACT:
A disubstituted piperazine compound having the formula I ##STR1## wherein R.sup.1 is thienyl or phenyl, which may be substituted with C.sub.1-6 -alkyl or halogen, and R.sup.2 is thienyl, which may be substituted with C.sub.1-6 -alkyl or halogen, and R.sup.3 is C.sub.1-8 -alkyl, C.sub.3-8 -alkenyl or C.sub.3-8 -cycloalkyl which all may be substituted with hydroxy, oximino or keto in any position giving a stable tertiary amine or R.sup.3 is C.sub.1-8 -alkyl or C.sub.3-8 -alkenyl which in any position may be substituted as above, but is terminally substituted with phenoxy, phenyl, thienyl, furyl, methoxy or --CN and pharmaceutically acceptable acid addition salts thereof.
The compounds are useful in the treatment of mental disorders in which a dopaminergic deficit is implicated.

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Rueger et al, Chemical Abstracts, vol. 111, No. 57757 (1989) (Abstract for DE 3,726,068, Feb. 16, 1989).
Michael R. Kilbourn, Nucl. Med. Biol., vol. 16, No. 7, pp. 681-686 (1989).

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