Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-03-18
2000-03-21
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540592, A61K 3155, C07D40106, C07D40114
Patent
active
060403020
ABSTRACT:
The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
REFERENCES:
patent: 3780035 (1973-12-01), Nakanishi et al.
Sindelar et al., Collection Czech. Chem. Commun., vol. 59, pp. 667-674 (1994).
Andersen Knud Erik
Hohlweg Rolf
J.o slashed.rgensen Tine Krogh
Konigova Otylie
Kovandova Martina
Bernhardt Emily
Novo Nordisk A S
Rozek Carol E.
Zelson Steve T.
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