1,4-disubstituted piperazine ligands for neurotransmitter...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S255030, C544S238000, C544S360000, C544S359000, C544S400000

Reexamination Certificate



One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including serotonin receptors and dopamine receptors. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, Tourette's syndrome, psychiatric disorders, stroke, and senile dementia.

patent: 2833770 (1958-05-01), Parcell et al.
patent: 6071920 (2000-06-01), Leonardi et al.
patent: 0 048 045 (1982-03-01), None
Anneke Hackling et al., N-(omega-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dpoamine D2 and D3 Receptor Ligands, J. Med. Chem. 46, pp. 3883-3899, 2003.


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