1,4-Disubstituted piperazine derivatives useful as...

Details 1,4-Disubstituted piperazine derivatives useful as... 1,4-Disubstituted piperazine derivatives useful as...

2005-07-05

2005-07-05

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S373000

Reexamination Certificate

active

06914064

ABSTRACT:
The present invention relates to a novel 1,4-disubstituted piperazine derivatives of Formula I,and their pharmaceutically acceptable acid addition salts having excellent uro-selective α1-adrenoceptor antagonistic activity exceeding those of previously described compounds. The compounds of the present invention hold promise for treating the symptoms of benign prostatic hyperplasia (BPH). The invention also relates to methods for making the novel compounds, pharmaceutical compositions containing the compounds, and method of treating the symptoms of benign prostatic hyperplasia using the compounds.

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