1,4-Disubstituted piperazine compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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424250, 544393, 544394, 260456R, 560264, 560266, 562430, 562452, 562472, 562607, 564 93, 568644, 568649, 568651, C07D40510

Patent

active

043363822

ABSTRACT:
There are disclosed compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n --wherein n is 2 to 20, ##STR2## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy, and ##STR3## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n --wherein n is 2 to 20, ##STR4## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy and racemates thereof.
There are also disclosed processes and intermediates utilized to produce the end products.
The end products have utility as agents exhibiting both .alpha. and selective .beta. adrenergic blocking action.

REFERENCES:
patent: 3029241 (1962-04-01), Fancher et al.
patent: 3211735 (1965-10-01), de Stevens et al.
patent: 3270004 (1966-08-01), Alter
patent: 3701777 (1972-10-01), Edenhofer et al.
patent: 3965106 (1976-06-01), Maruyama et al.

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