Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-05-10
1998-06-16
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3144
Patent
active
057671362
ABSTRACT:
The subject invention provides methods for preventing, retarding, or reducing atherosclerotic lesions or atherosclerotic degradation of aterial walls or treating atherosclerosis comprising administering to a mammal in need of such prevention, retardation, reduction or treatment at least one compound having the formula I: ##STR1## wherein: Ph is phenyl,
REFERENCES:
patent: 4089969 (1978-05-01), Muchowski et al.
patent: 4705797 (1987-11-01), Nardi et al.
patent: 4772621 (1988-09-01), Nardi et al.
patent: 5091182 (1992-02-01), Ong et al.
Albertson, Org. React., 12:157 (1962).
Staab et al., Newer Methods Prep. Org. Chem., 5:61 (1968).
Ross, J. Cell Bio., 50:172 (1971).
Ross et al., Science 180:1332 (1973).
Wissler et al., Prog. Cardiovasc. Dis., 18: 341 (1976).
Ross et al., N. Eng. J. Med., 295369 (1976).
Gimbrone, Prog. Hemostasis Thromb., 31 (1976).
Brown et al., J. Biol. Chem., 2559344 (1980).
Brown et al., Ann. Rev. Biochem., 52:223 (1983).
Edgell et al., Proc,. Natl. Acad. Sci, USA, 80:3734 (1983).
Ross, J. Biol. Chem., 259:815 (1984).
Bianchi et al., Ircs Med. Sci., 14(8):817 (1986).
Schwartz et al., Cir. Res.58:427 (1986).
Skalli et al., J. Cell Bio., 103:2787 (1986).
Bianchi et al., Pharmacol. Res., 21(2):193 (1989).
Clowes et al., J. Cardiov. Pharmacol., 14: S12, (1989).
Steinberg et al., N. Eng. J. Med., 320:915 (1989).
Steinbrecher, Curr. Opin, Lipidol.,1:411 (1990).
Harrison et al., J. Lipid. Res., 31:2187-2193 (1990).
Wissler et al., Ann. NY Acad. Sci., 598:418 (1990).
Steinberg et al., JAMA, 264:3047 (1990).
E.L. Bierman in Harrison's Principle of Internal Medicine XII Ed., p. 992 (1991).
Goldmann et al., Agnew Chem. Int. Ed. Engl, 30:1559 (1991).
Yla-Herttuala, Ann. Med., 23:561 (1991).
Wissler et al., Am. J. Med., 91:(S1B), 1B-3S (1991).
Ashimori et al., Chem. Pharm. Bull., 39:108 (1991).
Steinberg, Circulation, 84: 1420 (1991).
Kurihara et al., Curr. Opin. Lipidol, 2:295 (1991).
Corsini et al., Pharm. Res., 23173 (1991).
Ishihara, Chem. Pharm. Bull., 39:3236 (1991).
Doherty et al., J, Med. Chem., 35:2-14 (1992).
Parthasarathy et al., Prog. Lipid Res., 31:127 (1992).
Bernini et al., Atherosclerosis, 104:19 (1993).
De Lorenzi et al., Chirality, 5(8):622 (1993).
Ross, Nature, 362:801 (1993).
Hanna et al., Biochem, Pharmacol., 45:753 (1993).
Corsini et al., Atherosclerosis, 101:177 (1993).
Witztum. Lancet 344:793 (1994).
Maggie et al., Arteriosclerosis and Thromb., 14:1892 (1994).
Maggie et al., J. Hypertension, 13:129 (1995).
Drugs of the Future, 20(12):1284 (1995).
Leonardi Amedeo
Sartani Abraham
Testa Rodolfo
Criares Theodore J.
Recordati S.A. Chemical and Pharmaceutical Company
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