1,4-Dihydropyridines substituted by 3-aryloxy-2-hydroxypropyl am

Details 1,4-Dihydropyridines substituted by 3-aryloxy-2-hydroxypropyl am 1,4-Dihydropyridines substituted by 3-aryloxy-2-hydroxypropyl am

1986-02-11

1989-10-10

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514338, 514318, 514255, 514332, 514339, 514312, 514333, 5142362, 546321, 546271, 546194, 546158, 546272, 546256, 546273, 546263, 546270, 544131, 544365, C07D21186, A61K 31455

Patent

active

048732540

ABSTRACT:
A dihydropyridine of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each is alkyl, alkenyl or alkoxyalkyl, wherein R.sup.3 and R.sup.4 each is alkyl, wherein benzene ring A is unsubstituted or bears one or more additional substituents selected from halogeno, cyano, nitro, trifluoromethyl and alkyl, or bears the substituent .dbd.N--O--N.dbd. attached to the 5- and 6-positions, wherein Ar is as defined in the specification, wherein p is 0 or 1, wherein X is --O-- or --S--, and wherein Y is straight-or branched-chain alkylene or alkenylene each of 2 to 12 carbon atoms which may optionally be interrupted by one or two groups selected from oxygen, sulphur, imino, substituted imino, phenylene, substituted phenylene, pyridylene, cycloalkylene, 1,4-piperazinediyl, 1,4-piperidinediyl and amido groups; or an acid-addition salt thereof, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess either beta-adrenergic blocking or calcium ion slow channel blocking properties, or both such properties, and may be used in the treatment of hypertension.

REFERENCES:
patent: 4500527 (1985-02-01), Loev et al.
J. J. Baldwin et al., "Approches to Vasodilating/Beta-Adrenergic Blocking Agents: Examples of the Dihydrolutidine Type", Journal of Medicinal Chemistry, vol. 24, No. 5, pp. 628-631, May 1981.

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