Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-13
1995-11-28
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514252, 514253, A61K 31445, A61K 31495
Patent
active
054708605
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP92/02807 filed Dec. 4, 1992.
TECHNICAL FIELD
The invention relates to the new use of known dihydropyridines for the preparation of medicaments for the treatment of dermatoses.
PRIOR ART
A series of patent applications and patents describes the suitability of compounds from various classes of substance for the treatment of skin diseases. For example, it is said that certain xanthine derivatives (see e.g. EP 389 282, EP 267 676, EP 260 127, WO 87/04435 and EP 195 496) and certain imidazo-quinazoline derivatives (see e.g. U.S. Pat. No. 4,837,239, U.S. Pat. No. 4,690,925, U.S. Pat. No. 4,663,320, EP 212 647, EP 153 152 and EP 116 948) are suitable for the treatment of inflammatory skin diseases. European Patent Application EP-A-296 316 describes enantiomerically pure 1,4-dihydropyridines as effective vasodilators with coronary-therapeutic properties.
BRIEF DESCRIPTION OF THE DRAWING
FIGS. 1 and 1a represent the general structure of the compound employed herein (Formula I) and of the moiety formed by R5 and R6 defined below (Formula Ia).
DESCRIPTION OF THE INVENTION
It has now been found that the 1,4-dihydropyridines described in more detail below are outstandingly suitable for the treatment of dermatoses.
The invention therefore relates to the use of 1,4-dihydropyridines of the formula I (see formula sheet attached as FIG. 1), in which 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxy which is substituted completely or partially by fluorine, 1-4C-alkoxycarbonyl, 2-5C-acyl, amino, or mono- or di-1-4C-alkylamino, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxy which is substituted completely or partially by fluorine, 1-4C-alkoxycarbonyl, 2-5C-acyl, amino, or mono- or di-1-4C-alkylamino, --(CH.sub.2).sub.m --E--(CH.sub.2).sub.n -- or the group --A1--O--A2--, are a radical of the formula Ia (see formula sheet attached as FIG. 1), in which --CH.sub.2 --CHR9--CH.sub.2 --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CHR10--, are identical or different and are hydrogen (H), 1-4C-alkyl, 1-4C-alkoxy, halogen, hydroxyl, trifluoromethyl or together are methylenedioxy, medicaments for the treatment of dermatoses.
1-6C-alkyl is straight-chain or branched and is, for example, a hexyl, neopentyl, isopentyl, butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl or, in particular, an ethyl or methyl radical.
1-4C-alkyl is straight-chain or branched and is, for example, a butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl, ethyl or, in particular, a methyl radical.
1-4C-alkoxy contains, in addition to the oxygen atom, one of the abovementioned 1-4C-alkyl radicals. The methoxy and ethoxy radical are preferred.
1-4C-alkoxy-2-4C-alkyl is a butyl, propyl or, in particular, an ethyl radical, which is substituted by one of the abovementioned 1-4C-alkoxy radicals. The methoxyethyl radical is preferred.
Halogen in the context of the invention is bromine, fluorine and, in particular, chlorine.
1-4C-alkoxy substituted completely or partially by fluorine is, for example, 1,1,2,2-tetrafluoroethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy or, in particular, difluoromethoxy.
1-4C-alkoxycarbonyl contains, in addition to the carbonyl group, one of the abovementioned 1-4C-alkoxy radicals.
2-5C-acyl contains, in addition to the carbonyl group, one of the abovementioned 1-4C-alkyl radicals. The acetyl radical is preferred.
Mono- or di-1-4C-alkylamino contains, in addition to the nitrogen atom, one or two of the abovementioned 1-4C-alkyl radicals. Di-1-4C-alkylamino is preferred, particular preference in this case being given to dimethyl-, diethyl- or diisopropylamino.
Straight-chain or branched 1-5C-alkylene is, for example, methylene (--CH.sub.2 --), ethylene (--CH.sub.2 --CH.sub.2 --), trimethylene (--CH.sub.2 --CH.sub.2 --CH.sub.2 --), tetramethylene (--CH.sub.2 --CH.sub.2 --C.sub.2 --CH.sub.2 --), 1,2-dimethylethylene [--CH(CH.sub.3)--CH(CH.sub.3)--], 1,1-dimethylethylene [--C(CH.sub.3).sub.2 --CH.sub.2 --], 1,1-dimethylpropylene [--C(CH.sub.3).sub.2 --CH.sub.2 --CH.sub.2 --], 2,2-dimethylethylene [--CH.su
REFERENCES:
patent: 4994461 (1991-02-01), Ulrich
patent: 5326772 (1994-07-01), Klemm et al.
ByK Gulden Lomberg Chemische Fabrik GmbH
Henley III Raymond
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