Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1986-07-25
1989-06-13
Jane, T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
546194, 546263, 546278, 546275, 546280, 546279, 546121, 546285, 546256, 546257, 546284, 546281, 546193, 546187, 546 22, 546321, 546270, 544364, 544359, 544333, 544405, 514356, 514340, 514341, 514342, 514343, 514316, 514318, 514252, 514255, 514332, 514333, C07D40104, C07D40112, C07D21186, A61K 31455
Patent
active
048393487
ABSTRACT:
Dihydropyridines of formula I ##STR1## wherein R is hydrogen or lower alkyl; R.sub.1 is a CN, NO.sub.2, COCH.sub.3, COPh group, a carboalkoxy or carboamide group; R.sub.2 is an aromatic or heteroaromatic, mono- or bicyclic eventually substituted phenyl group; R.sub.3 is a carboalkoxy group; while A is a halogen atom or an ammonium or phosphonium residue. The compounds I are useful as antihypertensive, antitumoral, antimetastatic, antithrombotic, and/or antiischemic agent.
REFERENCES:
patent: 4284634 (1981-08-01), Sato
patent: 4532248 (1985-07-01), Frankowiak et al.
Cupka et al., Chemical Abstracts 105:226293w.
Franckowiak et al., "The Optical Isomers . . . " European Journal of Pharmacology, 114 (1985), pp. 223-226.
Seidel, Wolfgang, "QSAR and Molecular . . . " 2nd European Seminar & Exhi. on Computer Aided Molecular Design.
Hof, R. P. et al., "Stereoselectivity at the . . . " Journal of Cardiovascular Pharmacology, 1985, pp. 689-693.
Schachtele, C. et al., "Stereoselective Inhibition . . . " Naunyn-Schmiedeberg's Arch. of Phar. 1987, pp. 340-343.
Three Onoda Papers to Wayne State University.
Honn, K. et al., "Calcium channel . . . " Proceedings of the Soc. for Exptl. Biology & Medicine 174, (1983), pp. 16-19.
Onoda, J. et al., "Cisplatin and Nefedipine . . . " Cancer Letters, 3 (1986), pp. 181-188.
Onoda, J. et al., "Calcium Channel Blockers: . . . " Hemostatic Mech & Metastasis Martinus-Nighoff, The Hague, 1984, pp. 207-226.
Onoda, J. et al., "Antithrombogenic Effects of Calcium . . . " Thromobosis Research 34; 1984, pp. 367-378.
Cupka, P. et al., "Synthesis of 2-Chloromethyl-1 . . . " Drug Res. Institute, Palarikova 31, 811 04 Bratislava, Czechoslovakia.
Frigerio Marco
Gandolfi Carmelo A.
Spinelli Silvano
Tofanetti Odoardo
Tognella Sergio
Boehringer Biochemia Robin S.p.A.
Jane T.
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