1,4-Dihydropyridines

Details 1,4-Dihydropyridines 1,4-Dihydropyridines

1974-08-28

1976-05-25

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029369, 2602949, 260295AM, 2602955R, 260296R, 424263, 424266, C07D21355

Patent

active

039592960

ABSTRACT:
Derivatives of 4-substituted phenyl 1,4-dihydropyridine 3,5-dicarboxylic acids substituted by lower alkyl groups in the 2- and 6-positions, are cardiovascular agents. The compounds, of which 2,6-dimethyl-4-[2-(diethylaminoethoxy)-phenyl]-1,4-dihydropyridine-3,5-dic arboxylic acid 3,5-diethyl ester is a typical example, can be prepared through condensation of a .beta.-dicarbonyl compound with an amine and an aldehyde, of an ylidene-.beta.-ketocarboxylic acid ester, with a .beta.-ketocarbonyl compound and an amine, of an aldehyde, an enamine and a .beta.-ketocarbonyl compound, or through elaboration of the substituent on the phenyl group.

REFERENCES:
patent: 3862161 (1975-01-01), Bossert et al.
patent: 3862162 (1975-01-01), Meyer et al.
patent: 3867393 (1975-02-01), Meyer et al.

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