Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1976-02-02
1977-08-23
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
2602564R, 260287R, 260287D, 2602948D, 2602948F, 2602948G, 2602949, 2602955R, 2602955B, A61K 31455, C07D21355
Patent
active
040441415
ABSTRACT:
1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4-position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1,2 and 6-positions are coronary dilating, spasmolytic and hypotensive agents. The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbobenzoxy-1,4-dihydropy ridine is a representative embodiment, are prepared through the reaction of an ylidene-.beta.-dicarbonyl compound, which may be generated in situ from the corresponding .beta.-dicarbonyl compound and an aldehyde, and an enaminocarboxylic acid ester, which may also be generated in situ from a .beta.-dicarbonyl compound and an amine.
REFERENCES:
patent: 3996234 (1976-12-01), Bossert et al.
Bossert Friedrich
Kazda Stanislav
Stoepel Kurt
Vater Wulf
Wehinger Egbert
Bayer Aktiengesellschaft
Rotman Alan L.
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