1,4-Dihydropyridines

Details 1,4-Dihydropyridines 1,4-Dihydropyridines

1988-01-28

1990-03-27

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 15, 546283, 546321, C07D491056

Patent

active

049122231

ABSTRACT:
This invention provides novel compounds represented by the general formula: ##STR1## R.sub.1 and R.sub.2 are each independently selected from the group consisting of hydrocarbyl radicals and heteroatom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of nitrogen, oxygen, sulfur, phosphorus and halogen atoms; A is a straight or branched chain hydrocarbon moiety containing from 1 to 12 carbon atoms and from 0 to 2 double bonds; R.sub.3 is selected from the group consisting of oxa- or dioxacycloalkanyl radicals which may be substituted with one or more hydroxy, keto, lower alkyl, phenyl or alkylenedioxy radicals; R.sub.4 is an aryl or heteroaryl radical; and R.sub.5 is a lower alkyl radical or A-R.sub.3 ; and pharmaceutically-acceptable salts thereof. These compounds are useful for treating coronary insufficiency, hypertension, angina pectoris, cardiac arrythmia, heart attack, or coronary vasospasm.

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