1,4-dihydropyridines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514339, 514343, 546321, 546273, 546281, C07D21186, A61K 31455

Patent

active

048494364

ABSTRACT:
This invention provides compounds useful for treating coronary insufficiency, hypertension, angina pectoris, cardiac arrythmia, heart attack or coronary vasospasm and represented by the general formula: ##STR1## R.sub.1 and R.sub.2 are each independently selected from the group consisting of lower alkyl, N-alkylphthalimido and derivatives of N-alkylphthalimido, wherein said N-alkyl group comprises at least 2 carbon atoms;

REFERENCES:
patent: 3325505 (1967-06-01), Loev
patent: 3441648 (1969-04-01), Loev et al.
patent: 3455945 (1969-07-01), Loev
patent: 3470297 (1969-09-01), Bossert et al.
patent: 3485847 (1969-12-01), Bossert et al.
patent: 3488359 (1970-01-01), Bossert et al.
patent: 3511837 (1970-05-01), Bossert et al.
patent: 3511847 (1970-05-01), Loev et al.
patent: 3644627 (1972-02-01), Bossert et al.
patent: 3691177 (1972-09-01), Bossert et al.
patent: 3905970 (1975-09-01), Bossert et al.
patent: 3985758 (1976-10-01), Murakami et al.
patent: 4145432 (1979-03-01), Sato
patent: 4177278 (1979-12-01), Bossert et al.
patent: 4188395 (1980-02-01), Bossert et al.
patent: 4258042 (1981-03-01), Loev et al.
patent: 4284634 (1981-08-01), Satu
patent: 4307103 (1981-12-01), Sato
patent: 4338322 (1982-07-01), Sato
patent: 4348395 (1982-09-01), Franckowiak et al.
patent: 4360520 (1982-11-01), Meyer et al.
patent: 4370334 (1983-01-01), Sato
patent: 4393070 (1983-05-01), Sato et al.
patent: 4430333 (1984-02-01), Campbell et al.
patent: 4446325 (1984-05-01), Ohno et al.
patent: 4448964 (1984-05-01), Muto et al.
patent: 4450165 (1984-05-01), Araki et al.
patent: 4478834 (1984-10-01), Shroff et al.
patent: 4483985 (1984-11-01), Wehinger et al.
patent: 4485239 (1984-11-01), Biseniex et al.
patent: 4487932 (1984-12-01), Biseniex et al.
patent: 4491581 (1985-01-01), Vogel
patent: 4491582 (1985-01-01), Loev et al.
patent: 4492703 (1985-01-01), Goldmann et al.
patent: 4495192 (1985-01-01), Muto et al.
patent: 4495356 (1985-01-01), Inoue et al.
patent: 4497808 (1985-02-01), Zimmermann et al.
patent: 4500527 (1985-02-01), Loev et al.
patent: 4500528 (1985-02-01), Loev et al.
patent: 4500532 (1985-02-01), Loev et al.
patent: 4503223 (1985-03-01), Reilly, Jr.
patent: 4505920 (1985-03-01), Loev et al.
patent: 4508719 (1985-04-01), Tricerri et al.
patent: 4520131 (1985-05-01), Loev et al.
patent: 4532248 (1985-07-01), Franckowiak et al.
patent: 4568677 (1986-02-01), Alker et al.
patent: 4622332 (1986-11-01), Wehinger et al.
patent: 4652573 (1987-03-01), Minaskanian et al.
patent: 4732985 (1988-03-01), Alker et al.
Wolfe, S. et al. Canadian Journal of Chemistry, vol. 48 (1970) pp. 3572-3579.
Ferry, D. R. et al. FEBS Letters 169 (1) pp. 112-118 (1984).
Janis, et al., "New Developments in Ca.sup.2+ Channel Antagonists", J. Med. Chem. 26(6), 762-769 (1983).
Thayer, et al., "An Antibody to Dihydropyridine Calcium Entry Blockers," Biochemical Pharmacology 35(24), 4479-4485 (1986).
Bossert, et al., "4-Aryldihydropyridines, A New Class of Highly Active Calcium Antagonists," Angew. Chem. Int. Ed. Engl. 20, 762-769 (1981).
Hogestatt, et al., "Effects of Nifedipine on Potassium-Induced Contraction and Noradrenaline Release in Cerebral and Extracranial Arteries from Rabbit," Acta Physiol Scand 114:283-296 (1982).
Meyer, H., et al., Chapter 9, "Calcium Antagonists--New Opportunities," Annual Rpts. Med. Chem. 18, 79-88 (1983).
Schramm, M., et al., "Novel Dihydropyridines with Positive Inotropic Action Through Activation of Ca.sup.2+ Channels," Nature 303, 535-537 (1983).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

1,4-dihydropyridines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,4-dihydropyridines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,4-dihydropyridines will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-172606

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.