Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-06-30
1989-09-19
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514210, 514218, 514253, 514258, 514275, 514291, 514301, 514302, 514334, 514341, 540481, 540597, 540598, 540599, 540600, 540601, 544284, 544295, 544360, 544370, 546 89, 546114, 546115, 546289, 546255, 546256, 546257, 546262, 546263, 546264, 546266, 546267, 546286, 546287, 546289, 548 95, A61K 31395, A61K 3144, A61K 31435, A61K 31495, A61K 31505, C07D40102, C07D40112, C07D40114
Patent
active
048681814
ABSTRACT:
1,4-Dihydropyridine derivatives which combine both calcium agonist and alpha.sub.1 -antagonist activity are useful in treating congestive heart failure. These derivatives are compounds having the formula: ##STR1## wherein Ar, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined in the specification.
REFERENCES:
patent: 3985758 (1976-10-01), Murakami et al.
patent: 4248873 (1981-02-01), Bossert et al.
patent: 4256749 (1981-03-01), Horstmann et al.
patent: 4448964 (1984-05-01), Muto et al.
patent: 4532248 (1985-07-01), Franckowiak et al.
patent: 4537881 (1985-08-01), Heiker et al.
Nature, vol. 303, 9 Jun. 1983, pp. 535-537.
Biochemical and Biophysical Research Communications, vol. 118, No. 3, Feb. 14, 1984, pp. 842-847.
Arzneim-Forsch Drug Research, vol. 33 (11), Nr 9, 1983, pp. 1268-1272.
E. Schroder et al., "Pharmazeutische Chemie", 1982, pp. 677, 678, Publisher George Thieme, Stuttgart.
Progress in Pharmacology, vol. 5/1, 1982, pp. 25-52, Stuttgart; R. Mannhold et al.: "Qualitative and Quantitative Structure-Activity Relationships of Specific Ca Antagonists", FIG. 10, p. 44.
Chemical & Pharmaceutical Bulletin, vol. 33, No. 9, Sep. 1985, pp. 3787-3797, Tokyo, JP; K. Meguro et al.: "New 1,4-dihydropyridine Derivatives with Potent and Long-Lasting Hypotensive Effect", Example 33, p. 3791.
Johnson Alexander L.
Ma Philip
Timmermans Petrus B. M. W. M.
Wexler Ruth R.
Black Robert W.
E. I. Du Pont de Nemours and Company
Fato Gildo E.
Shen Cecilia
LandOfFree
1,4-dihydropyridine derivatives with calcium agonist and alpha.s does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,4-dihydropyridine derivatives with calcium agonist and alpha.s, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,4-dihydropyridine derivatives with calcium agonist and alpha.s will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-368871