1,4-Dihydropyridine derivatives and pharmaceutical compositions

Details 1,4-Dihydropyridine derivatives and pharmaceutical compositions 1,4-Dihydropyridine derivatives and pharmaceutical compositions

1987-06-15

1989-10-31

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514290, 514312, 514332, 514335, 546156, 546170, 546110, 546101, 546263, 546261, A61K 3144, C07D40112

Patent

active

048777978

ABSTRACT:
Compounds are described of the formula ##STR1## wherein R.sub.1 is a nitro or trifluoromethyl group; R.sub.2 is a C.sub.1 -C.sub.6 alkyl group; R.sub.3 is a pyridyl or pyridyl N-oxide group which may be substituted with halogen, hydroxyl, haloalkyl, C.sub.1 -C.sub.6 alkoxy or C.sub.1 -C.sub.6 alkyl and further may be fused with a benzene or naphthalene ring, said ring being optionally substituted with C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halogen or haloalkyl, and a pharmaceutically acceptable acid addition salt thereof. The compounds of the formula (I) are of vasodilating and blood pressure lowering activities and thus may be useful for the treatment of cardiac diseases, cerebrovascular diseases and hypertension.

REFERENCES:
patent: 3862161 (1975-01-01), Bossert et al.
patent: 4497808 (1985-02-01), Zimmermann et al.
patent: 4656181 (1987-04-01), Sunkel et al.
patent: 4757071 (1988-07-01), Koyama et al.

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