1,4-Dihydropyridine derivatives

Details 1,4-Dihydropyridine derivatives 1,4-Dihydropyridine derivatives

1983-01-13

1983-11-29

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546279, 424266, C07D40114, C07D40112

Patent

active

044181973

ABSTRACT:
Novel 1,4-dihydropyridine derivatives of the formula [I] are provided: ##STR1## wherein R.sup.1 represents a C.sub.1-4 alkyl group or a C.sub.3-6 alkoxyalkyl group, R.sup.2 represents hydrogen or halogen, R.sup.3 is either nitro when R.sup.2 is hydrogen, or halogen when R.sup.2 is halogen, R.sup.4 represents a pyridyl group, a phenethyl group, an unsubstituted benzyl group, a substituted benzyl group having one or more suitable substituents, an unsubstituted phenyl group, or a substituted phenyl group having one or more suitable substituents, and A represents an unsubstituted hexamethylene group or a substituted hexamethylene group having one or two C.sub.1-3 alkyl groups. The 1,4-dihydropyridine derivatives have vasodilating and hypotensive activity which is kept for a long period, and are useful in the treatment of cardiovascular disease and hypertension.

REFERENCES:
patent: 3905970 (1975-09-01), Bossert et al.
patent: 3946027 (1976-03-01), Bossert et al.
patent: 4146627 (1979-03-01), Wehinger
patent: 4380547 (1983-04-01), Materne

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