1,4-dihydropyridine derivatives

Details 1,4-dihydropyridine derivatives 1,4-dihydropyridine derivatives

1991-11-29

1994-11-22

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546309, 546308, C07D21351

Patent

active

053670817

ABSTRACT:
1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.

REFERENCES:
patent: 4616002 (1986-10-01), Kamber et al.
Journal Of Medicinal Chemistry, vol. 33, No. 8, pp. 2216-2221, 1990, E. Pop, et al., "Antihypertensive Activity of Redox Derivatives of Tryptophan".
J. Am. Chem. Soc., vol. 107, No. 13, pp. 3981-3997, 1985, A. G. Talma, et al., "Reductions of Activated Carbonyl Compounds with Chiral Bridged 1,4-Dihydropyridines. An Investigation of Scope and Structural Effects".
J. Am. Chem. Soc., vol. 103, No. 8, pp. 2091-2093, 1981, P. Jouin, et al., "Asymmetric Reductions with 1,4-Dihydropyridines Contained in Chiral Macrocycles".
Tetrahedron Letters, No. 1, pp. 23-26, 1979, T. Endo, et al., "Synthesis of 1-Benzyl-1,4-Dihydronicotinamides Containing Dipeptides and Their Use in Asymmetric Reduction of Ethyl Benzoylformate".
Bull. Chem. Soc. Jpn., vol. 61, No. 10, pp. 3613-3618, 1988, I. Hamachi, et al., "Efficient Electron Flux Conversion From Strongly Hydrophilic NADH Model in the Transmembrane Electron Transfer by Flavolipid".
Chemistry Letters, pp. 391-394, 1977, T. Endo, et al., "Synthesis of 1,4-Dihydropyridines Containing Amino Acids and Reduction of Ethyl Benzoylformate".

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