1,4-dihydropyridine derivatives

Details 1,4-dihydropyridine derivatives 1,4-dihydropyridine derivatives

1989-03-14

1991-02-12

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546194, 546310, 514352, C07D40112, A61K 31445

Patent

active

049924516

ABSTRACT:
1,4-Dihydro-6-methyl-4-(substituted phenyl)pyridine-3,5-dicarboxylic acid esters have an amino group at the 2-position and at least one nitrooxy group in at least one of the ester groups. These compounds have a variety of valuable activities, including antihypertensive and Ca.sup.++ -blocking activities, leading to their use for the treatment of circulatory and coronary disorders. They may be prepared by condensation of appropriate substituted acetic acid esters.

REFERENCES:
patent: 3775422 (1973-11-01), Bosset et al.
patent: 3935223 (1976-01-01), Meyer et al.
patent: 4448964 (1984-05-01), Muto et al.
patent: 4472411 (1984-09-01), Hatayama et al.
patent: 4565824 (1986-01-01), Wehinger et al.
patent: 4579859 (1986-04-01), Ueda et al.
patent: 4603135 (1986-07-01), Meguro et al.

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