1-4-dihydropyridine derivative, process for preparing the same a

Details 1-4-dihydropyridine derivative, process for preparing the same a 1-4-dihydropyridine derivative, process for preparing the same a

1990-07-26

1992-10-27

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 514212, 514210, 514343, 546321, 546194, 546283, 540597, A61K 31455, C07D21186

Patent

active

051589630

ABSTRACT:
A 1,4-dihydropyridine derivative having the formula (I): ##STR1## wherein X is oxygen atom or nitrogen atom; when X is oxygen atom, R.sup.1 is hydrogen atom, a lower alkyl group, a lower cycloalkyl group, a lower alkenyl group or magnesium atom, when X is nitrogen atom, X-R.sup.1 group is NH.sub.2, NHR.sup.1', NR.sup.1' R.sup.1" or ##STR2## in which R.sup.1' is a lower alkyl group or a lower alkoxyalkyl group, R.sup.1" is a lower alkyl group and n is an integer of 2 to 6; R.sup.2 is a lower alkyl group, a lower cycloalkyl group or a lower alkoxyalkyl group and R.sup.3 is a lower alkyl group, formyl group, dimethoxymethyl group, cyano group or amino group, when X is oxygen atom and R.sup.1 is hydrogen atom or magnesium atom, R.sup.3 is methyl group, when X is nitrogen atom, R.sup.3 is methyl group, or a pharmaceutically acceptable salt thereof, some processes for preparing the same and a pharmaceutical composition containing the same. According to the present invention, a superior cerebral function improver can be provided.

REFERENCES:
patent: 4492703 (1985-01-01), Goldmann et al.
patent: 4497808 (1985-02-01), Zimmermann et al.
patent: 4510310 (1985-04-01), Wehinger et al.
patent: 4849433 (1989-07-01), Wehinger et al.
patent: 4874773 (1989-10-01), Hisaki et al.

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