1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives and

Details 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives and 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives and

1982-12-10

1986-10-21

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514222, 514228, 514230, 514232, 514233, 514236, 514252, 514256, 514278, 514318, 514333, 544 586, 544 82, 544122, 544131, 544295, 544333, 544365, 546 19, 546187, 546193, 546194, 546256, 546257, 546258, 546263, 546275, 546278, 546280, 2602433, 2602444, A61K 31445, A61K 3155, C07D40112, C07D40114

Patent

active

046186077

ABSTRACT:
1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives of the general formula: ##STR1## or acid addition salts thereof, wherein W is --CH.dbd. or --N.dbd.; Y is --CH.dbd.CH--, --O--, --S--, --CH.dbd.N(O)p-- (p is zero or 1) or --N(R)-- (R is hydrogen or lower alkyl); X.sup.1, X.sup.2 and X.sup.3 are the same or different, and are each hydrogen, halogen, nitro, trifluoromethyl, cyano or lower alkylthio; Z is aryl or 5- or 6-membered aromatic heterocyclic ring (which may have a substituent or two or three substituents which may be the same or different, and the substituent may be halogen, lower alkyl, lower alkoxy, lower alkanoylamino, cyano, nitro, lower alkylthio, trifluoromethyl, sulfamoyl, di-lower alkylsulfamoyl, amino or di-lower alkylamino); ##STR2## is 5- to 7-membered heterocyclic ring which may have nitrogen atom, oxygen atom, sulfur atom or unsaturated bond on the ring, and may be substituted by lower alkyl, lower alkoxycarbonyl, lower alkanoylamino, ethylenedioxy or --(CH.sub.2).sub.m --OR.sup.4 (R.sup.4 is hydrogen, lower alkyl or lower alkanoyl and m is 0, 1 or 2); R.sup.1 and R.sup.2 are the same or different, and are each lower alkyl; R.sup.3 is lower alkyl, aralkyl, heteroaralkyl; and n is an integer 1 to 5. Such compounds are useful as antihypertensive agents and as therapeutic agents for cardiac and cerebral circulation disorders.

REFERENCES:
patent: 4038399 (1976-07-01), Bossert et al.
patent: 4450165 (1984-05-01), Araki et al.
Araki et al, European Patent Application 60,897 (9-29-82).
Wehinger et al, Chemical Abstracts, vol. 95 (1981), No. 42922ec.
Central Patents Index Abstracts, No. 21613, D/13 (1981).
Yoshitomi, Chemical Abstracts, vol. 96 (1982), No. 199,719b; Substance Index, vol. 96, pp. 5774cs, 1279cs.

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