1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and

Details 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and

1986-04-28

1989-02-07

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546193, 546199, 544 48, 548155, C07D51304

Patent

active

048032794

ABSTRACT:
6-Aryl-2,3-dihydroimidazo[2,1-b]thiazoles and corresponding thiazines act as nucleophiles, either directly or in the form of Grignard reagents, with N-acylpyridinium salts to produce new 6-aryl-5-(N-acyl-1,4-dihydro-4-pyridyl)-2,3-dihydroimidazo-[2,1-b]thiazole s and corresponding thiazines. These are oxidized to give the corresponding pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines, which are active as inhibitors of the 5-lipoxygenase pathway of arachidonic acid metabolism.

REFERENCES:
patent: 4175127 (1979-11-01), Bender et al.
Chemical Abstracts, vol., 78, No. 25, pp. 418-419, 159620j (1973).
S. Kano, Yakugaku Zasshi, 92 51-58 (1972).
D. L. Comins, Tetrahedron Letters 24 2807 (1983).
K. Akiba et al., Tetrahedron Letters 23 429 (1982).
D. L. Comins et al., J. Org. Chem. 47 4315 (1982).

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