1,4-Dihydro-4-oxo-pyridylacetamido cephalosporins and their util

Details 1,4-Dihydro-4-oxo-pyridylacetamido cephalosporins and their util 1,4-Dihydro-4-oxo-pyridylacetamido cephalosporins and their util

1974-09-06

1979-05-08

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 27, 544 28, 544 25, A61K 31545, C07D50156, C07D50146

Patent

active

041536932

ABSTRACT:
Cephem derivatives of the formula ##STR1## wherein Z is 1,4-dihydro-4-oxo-1-pyridyl or the corresponding group substituted by one or more of alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, OH, F, Cl, Br, I, NO.sub.2 and NH.sub.2 ; and R is H, --OCOCH.sub.3 or -S-Het, wherein Het is 3-methyl-1,2,4-thiadiazolyl-5, 5-methyl-1,3,4-oxadiazolyl-2, 5-hydroxymethyl-1,3,4-oxadiazolyl-2, 5-methyl-1,3,4-thiadiazolyl-2, 5-hydroxymethyl-1,3,4-thiadiazolyl-2, tetrazolyl-5, 1-methyltetrazolyl-5, 1,2,3-triazolyl-4, 4-methyl-oxazolyl-2 or 1-oxidopyridinio-2, and the readily cleavable esters thereof and the physiologically acceptable salts thereof, possess anti-bacterial activity and can be prepared by reacting a 3-CH.sub.2 R-7-amino-3-cephem-4-carboxylic acid or a functional derivative thereof with a pyridone acetic acid of the formula Z-CH.sub.2 -COOH or a functional derivative thereof.

REFERENCES:
patent: 3218318 (1965-11-01), Flynn
patent: 3833570 (1974-09-01), Holdrege
patent: 3956287 (1976-05-01), Bamburg et al.
patent: 3956288 (1976-05-01), Bamburg et al.
patent: 4119775 (1978-10-01), Bamburg et al.

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