1,4-Dihydro-4-oxo-benzothiopyrano (4,3-b)pyridine-2-carboxylates

Details 1,4-Dihydro-4-oxo-benzothiopyrano (4,3-b)pyridine-2-carboxylates 1,4-Dihydro-4-oxo-benzothiopyrano (4,3-b)pyridine-2-carboxylates

1976-01-14

1977-11-29

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602948A, 2602948B, 260295A, 260295T, 260327TH, 2603452, C07D51314, A61K 31435

Patent

active

040606198

ABSTRACT:
Compounds of formula 1 ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different selected from the group consisting of hydrogen, halogen, nitro, trifluoromethyl, lower alkyl and lower alkoxy, or R.sup.1 and R.sup.2, R.sup.2 and R.sup.3, or R.sup.3 and R.sup.4 together form a CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 chain and R.sup.3 and R.sup.4, R.sup.1 and R.sup.4 and R.sup.1 and R.sup.2, respectively, are as defined above, R.sup.5 is hydrogen, lower alkyl or a radical of formula -Alk-OR.sup.6 wherein Alk is an alkylene selected from the group consisting of CR.sup.7 R.sup.8, CR.sup.7 R.sup.8 CR.sup.9 R.sup.10, CR.sup.7 R.sup.8 CR.sup.9 R.sup.10 CR.sup.11 R.sup.12 and CR.sup.7 R.sup.8 CR.sup.9 R.sup.10 CR.sup.11 R.sup.12 CR.sup.13 R.sup.14 wherein each of R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13 and R.sup.14 is hydrogen or lower alkyl and R.sup.6 is hydrogen or lower alkyl; R.sup.15 is hydrogen or lower alkyl; X is O, S, SO or SO.sub.2 ; and Y is O or NR.sup.16 wherein R.sup.16 is hydrogen or lower alkyl, are disclosed. The compounds of formula 1 are useful for treating allergic conditions and for treating microbial infections. Methods for the preparation and use of said compounds are disclosed.

REFERENCES:
patent: 3883551 (1975-05-01), Razdan et al.
Roberts et al., Basic Principles of Organic Chemistry, Benjamin Pub. p. 806, 1965.
Fieser & Fieser, Advanced Organic Chemistry, Reinhold Pub. pp. 634-635, 1961.

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