1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic

Details 1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic 1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic

1985-04-25

1986-04-15

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546321, C07D21355, A61K 31455

Patent

active

045828407

ABSTRACT:
A method of combating a disorder of the salt balance in a patient afflicted therewith comprising administering to such patient a salt-balance restoring effective amount of a vasodilating 1,4-dihydropyridine of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl with 1 to 4 carbon atoms, and the nitro radical is in the ortho- or meta-position of the phenyl radical.
The salt balance disorder may accompany the hypertensive disease or may also be aggravated by administering to such a patient a hypertension reducing agent.

REFERENCES:
patent: 3485847 (1969-12-01), Bossert et al.
patent: 4412986 (1983-11-01), Kawata et al.
patent: 4435409 (1984-03-01), Leibowitz et al.

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