1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C540S555000

Reexamination Certificate

active

07935695

ABSTRACT:
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

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patent: WO-2007/138039 (2007-12-01), None
Naruganahalli. Expert Opinion on Investigational Drugs, 2007, 16(7), pp. 1127-1130.
Harry et al. Expert Opinion on Drug Metabolism and Toicology, 2005, 1(4), pp. 701-713.
Van der Schyfet al. Expert Opinion on Investigational Drugs, 2006, 15(8), 873-876.
Decker et al. Expert Opinion on Drug Discovery, 2008, 3(9), pp. 1027-1040.

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