Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-12-22
1997-01-28
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544105, A61K 31535, C07D26536
Patent
active
055978207
ABSTRACT:
A 1,4-benzoxazine derivative of the following formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed. The compound of the present invention is useful as a medicament for preventing or treating disorders induced by intracellular acidosis during myocardial ischemia, such as cardiac dysfunction, myocardial necrosis, arrhythmia, reperfusion injury, and the like, which are observed in ischemic heart diseases (e.g. myocardial infarction, angina pectoris, etc.).
REFERENCES:
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"Effects of New Na.sup.+ /h.sup.+ Antiportner Inhibitor on Postischemic Reperfusion in Pig Heart", Journal of Cardiovascular Pharmacology, 23 (1994), pp. 72-78, Sack et al.
"Salt-Sensitive Hypertension in Transgenic Mice Overexpressing Na.sup.+ -Proton Exchanger", Circulation Research, 76, pp. 148-153, Kuro-o et al.
"Blockade of the Na.sup.+ /H.sup.+ Antiport Abolishes Growth Factor-induced DNA Synthesis in Fibroblasts", The Journal of Biological Chemistry, 259, pp. 4313-4319, L'Allemain et al.
Copy of the European Search Report dated Mar. 20, 1996.
Harada Kengo
Hori Manabu
Maruo Joji
Morita Tominori
Ohtaka Hiroshi
Datlow Philip I.
Kanebo Ltd.
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