1, 4-benzoxazine derivative and pharmaceutical compositions cont

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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544105, A61K 31535, C07D26536

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active

055978207

ABSTRACT:
A 1,4-benzoxazine derivative of the following formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed. The compound of the present invention is useful as a medicament for preventing or treating disorders induced by intracellular acidosis during myocardial ischemia, such as cardiac dysfunction, myocardial necrosis, arrhythmia, reperfusion injury, and the like, which are observed in ischemic heart diseases (e.g. myocardial infarction, angina pectoris, etc.).

REFERENCES:
patent: 3313813 (1967-04-01), Cragoe, Jr.
"Na.sup.+ /H.sup.+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation", Biochimica et Biophysica Acta, 988 (1989) pp. 73-97, Grinstein et al.
"Effects of New Na.sup.+ /h.sup.+ Antiportner Inhibitor on Postischemic Reperfusion in Pig Heart", Journal of Cardiovascular Pharmacology, 23 (1994), pp. 72-78, Sack et al.
"Salt-Sensitive Hypertension in Transgenic Mice Overexpressing Na.sup.+ -Proton Exchanger", Circulation Research, 76, pp. 148-153, Kuro-o et al.
"Blockade of the Na.sup.+ /H.sup.+ Antiport Abolishes Growth Factor-induced DNA Synthesis in Fibroblasts", The Journal of Biological Chemistry, 259, pp. 4313-4319, L'Allemain et al.
Copy of the European Search Report dated Mar. 20, 1996.

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