1,4-benzothiazine derivatives, compositions containing them and

Details 1,4-benzothiazine derivatives, compositions containing them and 1,4-benzothiazine derivatives, compositions containing them and

1985-11-27

1987-02-03

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514225, 544 32, 544 52, C07D41706, A61K 3154

Patent

active

046409165

ABSTRACT:
1,4-Benzothiazine derivatives of the formula; ##STR1## wherein R.sup.1 and R.sup.2 independently stand for hydrogen, halogen, a lower alkyl group, a lower alkoxy group or trifluoromethyl group, or R.sup.1 and R.sup.2, taken together, form a 5-7 membered ring represented by ##STR2## wherein n is an integer of 3 to 5 or a 5-6 membered ring represented by ##STR3## wherein m is 1 or 2, R.sup.3 and R.sup.4 independently stand for hydrogen, halogen, a lower alkyl group, a lower alkoxy group or trifluoromethyl group, R.sup.5 stands for hydrogen or a lower alkyl group, and A stands for an alkylene group or pharmaceutically acceptable salts thereof, are useful as prophylactic or therapeutic drugs for, among others, hypertension and ischemic cardiovascular diseases.

REFERENCES:
patent: 3089872 (1963-05-01), Krapcho

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