Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-12-23
1988-04-05
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540559, A61K 3155, C07D48704
Patent
active
047359412
ABSTRACT:
Aromatic 1,4-benxodiazepines with fused 5- or 6-membered heterocyclic rings which are antagonists of cholecystokinins and/or gastrin, and are useful in the treatment or prevention of CCK-related and/or gastrin-related disorders of the gastrointestinal, central nervous and appetite regulatory systems; compositions comprising these compounds; and methods of treatment employing these compounds.
REFERENCES:
patent: 4017492 (1977-04-01), Moffet
patent: 4530790 (1985-07-01), Monaghan et al.
patent: 4554272 (1985-11-01), Bock et al.
patent: 4559338 (1985-12-01), Bock et al.
patent: 4559339 (1985-12-01), Bock et al.
patent: 4563451 (1986-01-01), Bock et al.
patent: 4663321 (1987-05-01), Rock et al.
patent: 4684645 (1987-08-01), Chang et al.
Kubota et al., Euro. J. Pharm., 110 (1985) 225-231.
Maten et al. Horm. Metabol. Res. 18 (1986) 2-9.
Jensen et al. Biochimica et Biophysica Acta, 757 (1983) 250-258.
Gardner et al. Derivative of CCK-(26-32) as Cholecystokinin Recepter Antagonists in Guinea Pig Pancreatic Acini, pp. 292-295.
Jensen et al., Proglumide Analogues: Patent Cholecystokinin Recepter Antagonists, pp. G214-G220.
Makovec et al., New Glutamic Acid Dervatives with Patent Competitive and Specific Cholecystokinin Activity, pp. 1048-1051.
Makovec et al., New Glutamic and Aspartic Derviatives Eur. J. Med. Chem.-Chim. Ther., 1986-21, No. 1, pp. 9-20.
Bock Mark G.
Evans Ben E.
Freidinger Roger M.
Elder R. A.
Jiles Henry R.
Merck & Co. , Inc.
Meredith R. D.
Pfeiffer Hesna J.
LandOfFree
1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, u does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, u, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, u will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2233769