1,4-Benzodiazepine derivatives, pharmaceutical compositions ther

Details 1,4-Benzodiazepine derivatives, pharmaceutical compositions ther 1,4-Benzodiazepine derivatives, pharmaceutical compositions ther

1978-12-05

1979-10-09

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260239BD, 2602393D, A61K 3155, C07D24316

Patent

active

041706498

ABSTRACT:
New 1,4-benzodiazepine derivatives are disclosed which are substituted in 2-position by cyanomethylene or carbamoylmethylene and have the formula ##STR1## wherein R.sub.1 represents hydrogen, halogen, or nitro, R.sub.2 represents hydrogen or lower alkyl, R.sub.3 represents phenyl which may be substituted by halogen or CF.sub.3, and R.sub.4 represents cyano or carbamoyl. The compounds exhibit tranquilizing activities. The cyanomethylene-compounds are prepared by oxidizing corresponding cyanomethyl compounds with Cr-VI-oxide in an acidic reaction medium. The cyanomethylene-group can subsequently be hydrolyzed into the carbamoylmethylene group.

REFERENCES:
patent: 3998209 (1976-12-01), Milkowski et al.
patent: 4096141 (1978-06-01), Milkowski et al.
patent: 4125726 (1978-11-01), Walser et al.

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