1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives and salts ther

Details 1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives and salts ther 1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives and salts ther

1982-02-02

1984-07-10

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544179, 544212, 544238, 544347, 544360, 544366, 544374, 424249, 424250, 424251, C07D40310, C07D40312, A61K 31505, A61K 31495

Patent

active

044594070

ABSTRACT:
A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and a salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

REFERENCES:
patent: 4110327 (1978-08-01), Sarkawa et al.
Hori et al., Chem. and Pharm. Bulletin, vol. 29, (3) pp. 684-698, (1981), (I).
Hori et al., Chem. and Pharm. Bulletin, vol. 29, (6), pp. 1594-1605, (1981) (II).

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