1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition

Details 1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition 1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition

1980-07-16

1984-03-13

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544121, 544295, 544357, 544360, 544385, 544366, 544367, 544368, 544369, 544370, 544371, 544372, 544373, 544375, 544376, 544377, 544378, 544379, 424250, 424251, C07D40100, A61K 31495

Patent

active

044369212

ABSTRACT:
A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

REFERENCES:
Chem. Abstract, 92, p. 41991s, Saikawa et al., "2,3-Dioxopiperazine derivatives".
Chem. Abstract, 92, 41992t, Saikawa et al., "1,4-Disubstituted 2,3-dioxopiperazines".
Chem. Abstract, 87, 102380n, Saikawa et al., "2,3-Dioxopiperazines".
Hori, T. et al., Chem. Pharm. Bull., 29 (3), 684-698, (1981).
Hori, T. et al., Chem. Pharm. Bull., 29 (6), 1594-1605, (1981).

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