1,4,5-triphenyl pyrazolyl compounds for the treatment of inflamm

Details 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflamm 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflamm

1993-11-30

1995-03-28

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483751, 5483771, A61K 31415, C07D23112, C07D23114

Patent

active

054017653

ABSTRACT:
A class of 1,4,5-triphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I ##STR1## wherein R.sup.1 is one or more groups independently selected from hydrido, methyl, ethyl, methoxy, ethoxy, methylthio, methylsulfinyl, methylsulfonyl, hydroxy, nitro, amino, N-methylamino, acetamido, trifluoromethyl, bromo, iodo, fluoro and chloro; wherein R.sup.2 is selected from hydrido, methyl, ethyl, cyano, trifluoromethyl, difluorochloromethyl, difluoromethyl, pentafluoroethyl and heptafluoropropyl; wherein R.sup.3 is one or more groups independently selected from hydrido, methyl, ethyl, methoxy, ethoxy, methylthio, methylsulfinyl, methylsulfonyl, hydroxy, nitro, amino, N-methylamino, acetamido, trifluoromethyl, bromo, iodo, fluoro and chloro; and wherein R.sup.4 is methyl; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 3984431 (1976-10-01), Gueremy et al.
patent: 4095025 (1978-06-01), Newberry
patent: 5134142 (1992-07-01), Matsuo et al.
J. Mizoule et al, Arch. int. Pharmacodyn., 238, 305 (1979).
H. House et al, J. Amer. Chem. Soc., 79, 2490 (1957).
J. Grimshaw et al, J. Chem. Soc. Perkin. Trans. 1, 2096 (1977).
J. Wilshire, Aust. J. Chem., 27, 2041 (1974).
H. House et al, J. Amer. Chem. Soc., 83, 979 (1961).
M. Weissenfelds et al, J. Prakt. Chem., 315, 873 (1973).
V. Szabo et al, Acta. Chim. Acad. Sci. Hung., 98, 457 (1979).
H. Gnichtel et al, Liebigs Ann. Chem., 589 (1989).
I. Gambhir et al, J. Org. Chem., 27, 1899 (1962).
H. Biere, Arch. Pharm., 316, 608 (1983).

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