1,4,5,6-tetrahydropyrazine-2-carboxamides

Details 1,4,5,6-tetrahydropyrazine-2-carboxamides 1,4,5,6-tetrahydropyrazine-2-carboxamides

1999-04-30

2000-08-29

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D24106

Patent

active

061111066

ABSTRACT:
1,4,5,6-tetrahydropyrazine-2-carboxamides of formula: wherein R.sup.1 is hydrogen, alkyl, cycloalkyl or arylalkyl; R.sup.2 is alkyl, aryl, or arylalkyl and R.sup.3, R.sup.4 and R.sup.5 are hydrogen, acyl, aryl or arylalkyl or R.sup.2 forms an alicyclic system with R.sup.3 or R.sup.4 and the adjacent carbon atom(s), R.sup.6 being hydrogen or a group of formula R.sup.7 --C(.dbd.O)-- wherein R.sup.7 is hydrogen or alkyl. These compounds can be used in the production of piperazine carboxamides.

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Rossen, K. et al., "Asymmetric Hydrogenation of Tetrahydropyrazines: Synthesis of S-piperazine-2-tert-butylcarboxamide", Tetrahedron Letters, vol. 36, No. 36, pp. 6419-6422 (Rossen et al.).

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