Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-08-29
1997-08-19
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514596, 514597, A61K 3117
Patent
active
056589522
ABSTRACT:
1-[4-(4'-sulfanilyl)phenyl]urea and its various substituted derivatives can be used to decrease the infectiousness of and reduce the mortality associated with organisms of the genus Leishmania which are responsible for a group of conditions known as Leishmaniasis. This heretofore unrecognized use extends to the known derivatives of ureidodiaminodiphenyl sulfones and includes the novel aryl-ring hydroxylated series of sulfanilylphenylureas of the formula: ##STR1## wherein m and n can be the same or different and may each =0 or 1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are the same or different and are selected from the group consisting of hydrogen, hydroxyl, halo, C.sub.1 to C.sub.6 straight or branch chain alkyl, halo alkyl, polyhalo alkyl, alkoxy, cyano, amino, alkanoylamino, alkoxycarbonylamino, carboxy, alkoxycarbonyl, carbamoyl, acyl, R.sup.7, and R.sup.8 are the same or different and are selected from the group consisting of hydrogen, and C.sub.1 to C.sub.6 straight or branch chain alkyl Z is amino, acylamino, alkoxycarbonylamino, alkylamino, substituted amino or nitro;
or its pharmaceutically acceptable salts.
REFERENCES:
HCAPLUS Abstract 1976: 516760, Winkelmann et al. (1976).
HCAPLUS Abstract 1975: 4313, Aichinger et al. (1975).
HCAPLUS Abstract 1985: 100800, O'Doherty et al. (1985).
HCAPLUS Abstract 1981: 71498, Callender et al. (1981).
Pelczar, Jr., et al., Microbiology (5th Ed.), McGraw-Hill (1986) pp. 403-405.
Behr Esq. Omri M.
Cintins Marianne M.
Jacobus Pharmaceutical Co. Inc.
Moezie M.
LandOfFree
1-[4-(4'-sulfanilyl)phenyl]urea and derivatives for the treatmen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1-[4-(4'-sulfanilyl)phenyl]urea and derivatives for the treatmen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-[4-(4'-sulfanilyl)phenyl]urea and derivatives for the treatmen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1105276