1,3-Oxygenated-8.alpha.-estratrienes

Details 1,3-Oxygenated-8.alpha.-estratrienes 1,3-Oxygenated-8.alpha.-estratrienes

1974-07-12

1976-04-20

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023955R, 26023955D, 2603974, 2603975, C07J 7100

Patent

active

039519589

ABSTRACT:
1,3-Dihydroxy-8.alpha.-estratrienes of the formula ##SPC1##
Wherein R is lower-alkyl and --A--B is ##SPC2##
Wherein R' is a saturated or unsaturated hydrocarbon group and R" is lower-alkyl, aralkyl or phenyl, and the esters and ethers thereof, possess strong vaginotropic but only weak utertropic activity and are useful in the treatment of estrogenic deficiency conditions where uteral effects are not desired.

REFERENCES:
patent: 3686238 (1962-08-01), Zaffaroni

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