1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heteroc

Details 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heteroc 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heteroc

1992-07-10

1994-11-15

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514210, 5142358, 514253, 540598, 544121, 544359, 544360, 544372, A61K 3155, A61K 31535, C07D40302, C07D40100

Patent

active

053648498

ABSTRACT:
Piperazine derivatives of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R.sup.1 is an aryl or nitrogen containing heteroaryl radical, R.sup.2 is hydrogen or lower alkyl, R.sup.3 is aryl, C.sub.4-8 alkyl or aryl(lower)alkyl and X is a functionalised group of specified meaning. The compounds exhibit activity as 5-HT.sub.1A antagonists and can be used, into alia, for the treatment of CNS disorders, such as anxiety.

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