Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1979-06-29
1981-02-03
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
26032612R, 2603262, 26032625, 26032642, 26032643, 424273R, 548336, A61K 3140, C07D20709
Patent
active
042488834
ABSTRACT:
1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives of the formula ##STR1## wherein R represents a hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group or a substituted phenyl-lower alkyl group, R.sub.1 represents a hydrogen atom, R.sub.4 CO--, R.sub.5 S--, or ##STR2## R.sub.2 represents a hydrogen atom or a lower alkyl group, R.sub.3 represents a hydrogen atom, a phenyl group, a lower alkyl group, or a substituted lower alkyl group, or R.sub.2 and R.sub.3 form a heterocyclic ring together with the nitrogen and carbon atoms to which they are respectively bonded; salts of these compounds; compositions comprising these compounds or salts; and processes for preparing these compounds or salts. These compounds and salts have excellent antihypertensive activity.
REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4116962 (1978-09-01), Ondetti et al.
M. Ondetti, Angiotensin-Science, 196, 441-444, (1977), Design of Specific Angiotension-Converting Enzyme: New Class of Orally Active Antihypertensive Agents.
D. Cushman et al., Biochemistry, vol. 16, No. 25, (1977), Design of Potent Competitive Inhibitors of Angiotensin-Converting Enzyme.
Hosoki Kanoo
Kinugasa Hiroaki
Nishimura Haruki
Sawayama Tadahiro
Takeyama Kunihiko
Dainippon Pharmaceutical Co., Ltd.
Daus Donald G.
Eakin M. C.
LandOfFree
1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives an does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives an will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-551058