1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositio

Details 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositio 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositio

1975-07-21

1979-12-04

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

26032612R, 26032616, 546201, 546212, 546214, 546224, 546244, 546273, A61K 31445, C07D40106

Patent

active

041772792

ABSTRACT:
The invention provides compounds of general formula I ##STR1## and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents hydrogen or lower alkyl, R.sup.3 represents hydrogen, halogen, lower alkoxy, hydroxy, or lower alkyl, R.sup.4 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, thienyl, furyl, phenyl; phenyl mono- or disubstituted by halogen, lower alkyl, lower alkoxy, hydroxy or trifluoromethyl; or benzoyl, halobenzoyl, lower alkanoyl, cycloalkanoyl of 6 to 8 carbon atoms, or thienoyl, A represents an alkylene, mono- or diketo- or hydroxy-alkylene radical having from 1 to 5 carbon atoms and X is oxygen or sulphur.
The compounds exhibit action on the cardiovascular system particularly hypotensive and/or anti-hypertensive activity.

REFERENCES:
patent: 3183235 (1965-05-01), Zenitz
patent: 3217011 (1965-11-01), Zenitz
patent: 3527761 (1970-09-01), Archibald et al.
patent: 3655674 (1972-04-01), Archibald

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