1,3-genzoxazine, 2,4-dione derivatives

Details 1,3-genzoxazine, 2,4-dione derivatives 1,3-genzoxazine, 2,4-dione derivatives

1990-02-12

1991-11-12

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

546156, C07D26526

Patent

active

050649582

ABSTRACT:
Quinolonecarboxylic acid intermediates useful in the preparation of antibacterial 6-fluoro-7-substituted-quinolonecarboxylic aids are prepared from 2-(iodo, bromo or chloro)-3-fluoro-4-(fluoro or chloro)-phenyl carboxylic acid or ester.

REFERENCES:
patent: 3598823 (1971-08-01), Hardtmann
patent: 4563459 (1986-01-01), Grohe et al.
patent: 4623650 (1986-11-01), Gilligan et al.
Stenseth, J. Med. Chem. 6, 212-13, 1963 Chemical Abstract vol. 59, 1962, Abs. 612 c-f.
Morrison and Boyd Organic Chemistry (Allyn and Bacon, Boston, 1979), p. 733.
Coppola, J. Heterocyclic Chemistry, 20, 1983, pp. 1217-1221.
Mitscher et al., J. of Med. Chem., 22, 1354-1357 (1979).
Mitscher et al., J. of Med. Chem., 21, 485-489 (1978).

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