1,3-dithiolano-, 1,4-dithiino- and 1,4-dithiepino[2,3-C]pyrrole

Details 1,3-dithiolano-, 1,4-dithiino- and 1,4-dithiepino[2,3-C]pyrrole 1,3-dithiolano-, 1,4-dithiino- and 1,4-dithiepino[2,3-C]pyrrole

1986-04-23

1988-11-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 514253, 514254, 514256, 514269, 514273, 514323, 514421, 5142338, 544144, 544238, 544298, 544333, 544359, 544368, 544373, 540602, 540603, 546122, 546159, 546167, 546171, 546189, 546200, 548159, 548181, 548182, 548453, A61K 3133, A61K 31495, A61K 3150, A61K 31505, C07D41314, C07D40314, C07D40914

Patent

active

047881917

ABSTRACT:
The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH.dbd.CH--CH.dbd.CH--, --S--(CH.sub.2).sub.l --S-- (l is an integer of 1 to 3), --N.dbd.CH--CH.dbd.N-- or --(CH.sub.2).sub.m -- (m is an integer of 3 to 5); ring A may optionally be substituted with halogen, nitro, amino, alkanoylamino, alkoxycarbonyl, carboxyl or carbamoyl; and n is an integer of 1 to 3, and salts thereof. The compounds display a strong antianxiety effect to mammalian animals and are useful for the prevention or treatment of a disease such as psychoromatic disease and anxiety neurosis.

REFERENCES:
patent: 4164404 (1979-08-01), Los et al.
patent: 4327095 (1982-04-01), Faye et al.
Hiraga et al., CA 102-184970v.
Hiraga et al., CA 101-90982c.
Burger, Medicinal Chemistry, 2nd Edition, pp. 42-43.

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