Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-02-11
1989-04-04
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514441, 549 35, 549 39, 546284, 544148, 544374, C07D33906, C07D33908, A61K 31385
Patent
active
048187658
ABSTRACT:
The invention relates to the use of ketenethioacetals of the formula ##STR1## in which R.sub.1 represents aryl or heteroaryl, R.sub.2 represents hydrogen, an optionally substituted hydrocarbon radical, heteroaryl, an acyl radical, a group of the formula --S(O).sub.m --R.sub.a, wherein m is 0, 1, or 2 and R.sub.a is an optionally substituted hydrocarbon radical; or optionally functionally modified sulpho, A represents an optionally substituted bivalent aliphatic hydrocarbon radical and n is 0 or 1, and pharmaceutically acceptable salts of such compounds that contain a salt-forming group, for the treatment of liver diseases, respiratory tract diseases and vascular diseases pharmaceutical preparations containing compounds of the formula I and novel compounds of the formula I. The compounds have liver-protecting and immunomodulating properties.
REFERENCES:
patent: 3525751 (1970-08-01), Fried
patent: 3725394 (1973-04-01), Donche et al.
patent: 3781281 (1973-12-01), Hartzler
Robbins et al., Pathologic Basis of Disease, Third Edition, pp. 892-894 Saunders Co. Pub. 1984.
Loeb, Textbook of Medicine, Thirteenth Edition, pp. 1390-1398 Saunders Co. Pub. 1971.
Chemical Abstracts, vol. 68(16), abst. no. 73303q, Apr. 15, 1968.
Chemical Abstracts, vol. 72,(13), abst. no. 66,955h, Mar. 30, 1970.
Chemical Abstracts, vol. 100, (21), abst. no. 174,842z, May 21, 1984.
Corey, Tetrahedron Letters, No. 33, pp. 3201-3204 (1967).
Yanaka, Chem. Abstracts, vol. 84, Art. 84:175153p (1976).
Hirai, Chem. Abstracts, vol. 83, Art. 83:10035t (1975).
Tetrahedron Letter, 1, 1967, 3201-3204.
Handbook of Chemistry and Physics 51st Ed. 1970-71 pp. C-49.
Narbel Philippe M.
Weith Andrr J.
Ciba-Geigy Corporation
Fishman Irving M.
Rotman Alan L.
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