1,3-disubstituted pyrrolidines

Details 1,3-disubstituted pyrrolidines 1,3-disubstituted pyrrolidines

1993-09-08

1995-09-26

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514428, 548541, 548569, A61K 3140, C07D20712

Patent

active

054534372

ABSTRACT:
Novel 1,3-disubstituted pyrrolidines active on the central nervous system of the formula ##STR1## wherein A--denotes phenyl or hetaryl, which is optionally fused with aromatic, saturated or unsaturated cyclic or heterocyclic hydrocarbons, where this radical can optionally be substituted,

REFERENCES:
patent: 3577415 (1971-05-01), Cale, Jr.
patent: 3577432 (1971-05-01), Helsley
patent: 3642803 (1972-02-01), Welstead, Jr.
patent: 4067985 (1978-01-01), Grauduims et al.
patent: 4104388 (1978-08-01), Wade et al.
patent: 5037841 (1991-08-01), Schohe
Psychopharmakaforschung aktuell, Ansatze, Methoden, Ergebnisse, Symposium, Koln, Mar. 1989, Herausgeber T. Glaser, K. Heinrich, 5-HT.sub.1A -Rezeptoren als Angriffspunkt fur neuartige Anxiolytika Biochemische und verhaltenspharmakologische Aspeckte, Institut fur Neurobiologie, Troponwerk GmbH & Co. KG, pp. 49-62.
5-HT.sub.1A receptor-related anxiolytics, Jorg Traber and Thomas Glaser, TIPS, Nov. 1987, vol. 8, pp. 432-437.
Duncan et al "Synthesis and Biological Properties . . . " J. Med. Chem 12(3) 442-4 (1969) (8).

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