1,3-disubstituted piperidine compounds as neuroleptic agents

Details 1,3-disubstituted piperidine compounds as neuroleptic agents 1,3-disubstituted piperidine compounds as neuroleptic agents

1984-07-26

1986-06-03

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546240, 546237, C07D21122, A61K 31445

Patent

active

045930376

ABSTRACT:
Certain novel 1-(substituted-alkyl)-3-(3-hydroxyphenyl)piperidine compounds, and the pharmaceutically-acceptable acid-addition salts thereof, possess pharmaceutical activity as neuroleptic agents, and they are useful for treating psychotic disorders, e.g. schizophrenia, in human subjects. In particular, they are useful for alleviating such symptoms as anxiety, agitation, excessive agression, tension and social or emotional withdrawal in psychotic patients.
Certain 3-(3-methoxyphenyl)piperidine compounds are useful as chemical intermediates to the aforementioned neuroleptic agents.

REFERENCES:
patent: 4072685 (1978-02-01), Nedelec et al.
patent: 4241071 (1980-12-01), Martin et al.
patent: 4332942 (1982-06-01), Althuis et al.
Julia et al., Bulletin de la Societe Chimique de France, No. 3, 1000-1007 (1968).
Hacksell et al., Journal of Medicinal Chemistry, 24, 1475-1482 (1981).

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