1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514256, 514333, 514338, 514339, 514361, 514362, 514365, 514372, 514374, 514378, 514411, 514414, 514418, 544333, 544405, 546256, 546270, 546273, 548127, 548134, 548181, 548214, 548236, 548247, 548248, 548431, 548450, 548454, 548465, 548468, 548486, A61K 31495, A61K 3140, C07D24112, C07D20934

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047217120

ABSTRACT:
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also on the carboxamide nitrogen atom, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and anti-inflammatory agents in mammalian subjects. These 2-oxindole-1-carboxamide compounds are of particular value for acute administration for ameliorating pain in human patients recovering from surgery or trauma, and also for chronic administration to human subjects for alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis. Certain 2-oxindole-1-carboxamide compounds unsubstituted at C-3, but having an acyl substituent on the carboxamide nitrogen atom, are useful as intermediates to the aforementioned analgesic and anti-inflammatory agents.

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