Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-11-13
1988-01-26
Ceperley, Mary E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514256, 514333, 514338, 514339, 514361, 514362, 514365, 514372, 514374, 514378, 514411, 514414, 514418, 544333, 544405, 546256, 546270, 546273, 548127, 548134, 548181, 548214, 548236, 548247, 548248, 548431, 548450, 548454, 548465, 548468, 548486, A61K 31495, A61K 3140, C07D24112, C07D20934
Patent
active
047217120
ABSTRACT:
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also on the carboxamide nitrogen atom, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and anti-inflammatory agents in mammalian subjects. These 2-oxindole-1-carboxamide compounds are of particular value for acute administration for ameliorating pain in human patients recovering from surgery or trauma, and also for chronic administration to human subjects for alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis. Certain 2-oxindole-1-carboxamide compounds unsubstituted at C-3, but having an acyl substituent on the carboxamide nitrogen atom, are useful as intermediates to the aforementioned analgesic and anti-inflammatory agents.
REFERENCES:
patent: 3462450 (1969-08-01), Shen
patent: 3519592 (1970-07-01), Holden
patent: 3522272 (1970-07-01), Chemerda et al.
patent: 3631177 (1971-12-01), Holden
patent: 3634453 (1972-01-01), McManus et al.
patent: 3749731 (1973-07-01), Zinnes et al.
patent: 3856967 (1974-12-01), Allais et al.
patent: 3975531 (1976-08-01), Welstead et al.
patent: 4012394 (1977-03-01), Descamps et al.
patent: 4658037 (1987-04-01), Kadin
patent: 4665194 (1987-05-01), Crawford
McOnie, Protective Groups in Organic Chemistry, Plenum Press, New York (1923), 54-55.
Ariens, E. J., Drug Design, Academic Press, New York (1971), pp. 10-11.
Wenkert et al., Journal of the American Chemical Society, 80, 4899 (1958).
Bunnett et al., Organic Syntheses, vol. 40, 1 (1960).
Capuano et al., Chemische Berichte, 105, 2539 (1972).
El-Enany et al., Bulletin of the Faculty of Pharmacy (Cairo University), 14, 29 (1975).
Buchel et al., Z. Anal. Chemie, 190, 243 (1962).
Pakula et al., Chemical Abstracts, 72:12563(k) (1970).
Brenner et al., Chemical Abstracts, 72:12565(n) (1970).
Shen et al., Chemical Abstracts, 72:12566(p) (1970).
Akers Lawrence C.
Ceperley Mary E.
Lumb J. Trevor
Pfizer Inc.
Richardson Peter C.
LandOfFree
1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1468143