1,3-Disubstituted 2-azetidinone antibitotics

Details 1,3-Disubstituted 2-azetidinone antibitotics 1,3-Disubstituted 2-azetidinone antibitotics

1977-10-26

1980-03-25

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602454, 2603303, 2603473, 546275, 424244, C07D20508, A61K 31395

Patent

active

041950216

ABSTRACT:
Novel 3-acylaminoazetidin-4-one antibiotic compounds, prepared by reduction of known 2-chloroazetidin-4-one compounds with tri(butyl)tin hydride, are antinicrobial agents.

REFERENCES:
patent: 3993646 (1976-11-01), Kamiya et al.
patent: 4058521 (1977-11-01), Uyeo et al.
Heyningen et al. J. Med. Chem II, 933 (1968).
Sheehan "Tho Synthetic Penicillins", Ad. Chem. #45 (Molecular Modification in Drug Design, American Chem. Society, 1964 p. 15-23.

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