1,3-Dioxolane-5-yl-hexenoic acid derivatives

Details 1,3-Dioxolane-5-yl-hexenoic acid derivatives 1,3-Dioxolane-5-yl-hexenoic acid derivatives

1986-05-09

1989-04-25

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549375, 549373, 549370, 549362, 549350, 548268, 548254, 548253, 548252, 546268, 514452, 514450, 514382, A61K 31335, C07D31906

Patent

active

048248584

ABSTRACT:
The invention describes novel (2-styryl-, 2-naphthyl- and 2-phenethyl-4-o-hydroxyphenyl-1,3-dioxan-5-yl)alkenoic acids and related tetrazoles and sulphonamides, of the formula I wherein Q completes a benzene or pyridine ring, Y is vinylene, Z is carboxy, 1 (H)-tetrazol-5-yl or a group of the formula --CO.NHSO.sub.2 R.sup.6, and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, A.sup.1, A.sup.2, n and m have the meanings defined in the specification, and pharmaceutically acceptable salts thereof, for use in conjunction with their pharmaceutical compositions in treating certain pulmonary and/or vascular disorders. The invention also describes various processes and intermediates for the manufacture of the novel compounds.

REFERENCES:
patent: 4567197 (1986-01-01), Brewster et al.

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