[1,3-Dioxo-2-substituted and 2,2-disubstituted- indanyloxy (or t

Details [1,3-Dioxo-2-substituted and 2,2-disubstituted- indanyloxy (or t [1,3-Dioxo-2-substituted and 2,2-disubstituted- indanyloxy (or t

1973-10-12

1976-08-24

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260308D, 260465C, 260470, 260473R, 260516, 260520C, 260520R, 260544L, 260590FA, 424269, 424308, 424317, 424320, C07C 6976, C07C 6514

Patent

active

039766810

ABSTRACT:
[1,3-Dioxo-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids and their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a (2,2-di or 2-)substituted-6-hydroxy-(or mercapto)-1,3-indanedione with a haloalkanoic acid or ester thereof and if the ester is employed hydrolyzing the ester.

REFERENCES:
patent: 3668241 (1972-06-01), Cragoe et al.
patent: 3784606 (1974-01-01), Holland et al.

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