1,3-dioxane ethers

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514382, 549375, 549373, 548252, A61K 31335, C07D31906

Patent

active

047756845

ABSTRACT:
The invention concerns novel 1,3-dioxane ethers of the formula I, wherein R.sup.1 includes alkyl, cycloalkyl, phenyl and phenyalkyl, R.sup.2 and R.sup.3 include hydrogen and alkyl, n is 1 or 2, m is 2, 3 or 4, p is zero, 1 or 2, and Z is carboxy or 1(H)-tetrazol-5-yl, and pharmaceutically acceptable salts thereof, for use in conjunction with their pharmaceutical compositions in the treatment of certain pulmonary and/or vascular disorders. The invention also describes various processes and intermediates for the manufacture of the novel compounds.

REFERENCES:
patent: 4567197 (1986-01-01), Brewster et al.

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