1,3-dioxan-5-ylalkenoic acids

Details 1,3-dioxan-5-ylalkenoic acids 1,3-dioxan-5-ylalkenoic acids

1988-02-09

1992-11-24

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554 44, 554 45, 554 46, 554218, 560 10, 560 11, 560 12, 560 20, 560 21, 560 22, 560 23, 560 56, 560 57, 560 60, 560104, 560105, 562426, 562429, 562430, 562431, 562434, 562437, 562472, 562438, 562471, 562470, 562466, 564162, 564166, 564170, 564171, 564172, C07C10200, C07C 5900

Patent

active

051663775

ABSTRACT:
The invention concerns novel 4-phenyl-1,3-dioxan-5-ylalkenoic acid derivatives of the formula I having cis relative stereochemistry at positions 4 and 5 of the dioxane ring and wherein Ra and Rb are variously hydrogen, alkyl, halogenoalkyl, alkenyl, and optionally substituted aryl or arylalkyl, Rc is hydroxy, alkoxy or alkanesulphonamido, n is 1 or 2, A is ethylene or vinylene, Y is (2-5C)polymethylene optionally substituted by alkyl, and benzene ring B is optionally substituted phenyl, or, when Rc is hydroxy, a salt thereof. The acid derivatives antagonize one or more of the actions of thromboxane A.sub.2 (TXA.sub.2) and are expected to be of value in those disease conditions in which TXA.sub.2 is involved. The invention also provides pharmaceutical compositions containing an acid derivative of formula I, and processes for their chemical production.

REFERENCES:
Fried et al., "Advances in Prostaglandin and Thromboxane Research", vol. 6, pp. 427-436, 1980.

Affiliated with

Also associated with

Rating

1,3-dioxan-5-ylalkenoic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,3-dioxan-5-ylalkenoic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,3-dioxan-5-ylalkenoic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-923007