1,3-dioxan-5-yl-hexenoic acids

Details 1,3-dioxan-5-yl-hexenoic acids 1,3-dioxan-5-yl-hexenoic acids

1986-05-09

1988-09-20

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549375, A61K 31335, C07D31906

Patent

active

047726253

ABSTRACT:
The invention provides a novel group of 4(Z)-6-([2,4,5-cis]-2-alkyl-4-o-hydroxyphenyl-1,3-dioxan-5-yl)hexenoic acids of formula I wherein R is branched alkyl of 3-5 carbon atoms and one of X and Y is hydrogen or fluoro and the other is hydrogen, and their pharmaceutically acceptable salts; together with their pharmaceutical compositions for use in treating a variety of disease conditions. Also provided are methods for the manufacture of the novel compounds. A representative compound is that in which R is t-butyl ans X and Y are both hydrogen.

REFERENCES:
patent: 4567197 (1986-01-01), Brewster et al.

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